When Emily Elizabeth meets a magical animal rescuer who gives her a little red puppy, she never anticipated waking up to find a giant, 10-foot hound in her small New York City apartment. With her single mother away on business, Emily and her fun but impulsive uncle set out on an adventure that takes a bite out of the Big Apple.
As middle schooler Emily Elizabeth struggles to fit in at home and at school, she discovers a small red puppy who is destined to become her best friend from a magical animal rescuer. When Clifford becomes a gigantic red dog in her New York City apartment and attracts the attention of a genetics company that wish to supersize animals, Emily and her clueless Uncle Casey have to fight the forces of greed as they go on the run across New York City and take a bite out of the Big Apple. Along the way, Clifford affects the lives of everyone around him and teaches Emily and her uncle the true meaning of acceptance and unconditional love. Based on the beloved Scholastic character, Clifford will teach the world how to love big.